Attacking the sleeping sickness parasite

The Deadly Trypanosome: Understanding the Parasite that causes Sleeping Sickness

Sleeping Sickness Wakes Again

Sleeping sickness of horses was, as reeentiy as the IQSO's, the most devastating livestock disease in the United States. Horses died by the hundreds of thousands in the Midwestern United States, in California, and along the Atlantic seaboard at a period which coincided with the beginning of the sharp decline in the use of horses on the farm. Losses were so severe in some areas that the inevitab...

The Sleeping Sickness of Uganda

34 cases by the same method and found the Trypanosoma in 20 cases, or 70 per cent. An examination of 12 cases of other diseases including three of Trypanosoma fever in the same way gave negative results. The matter was then taken up by" Lieutenant-Colonel David Bruce, F.n.c.s., R A M C and Dr. David N. Nabarro, who had been deputed by the Royal Society to investigate sleeping sickness, and arri...

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei.

The tsetse fly-transmitted protozoan parasite Trypanosoma brucei is the causative agent of human African sleeping sickness and the cattle disease Nagana. The bloodstream form of the parasite uses a dense cell-surface coat of variant surface glycoprotein to escape the innate and adaptive immune responses of the mammalian host and a highly glycosylated transferrin receptor to take up host transfe...

Differentiation and apoptosis in the sleeping sickness inducing parasite Trypanosoma brucei

V. Denninger, K. Figarella, B. Kubata and M. Duszenko Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany Fundación Instituto de Estudios Avanzados, Centro de Biotecnología, Valle de Sartenejas, Carretera Hoyo de la Puerta, Caracas 1080, Venezuela NEPAD/Biosciences Eastern and Central Africa Network (BecANet), PO Box 30709, 00100 Nairobi,...